1.
J Med Microbiol
; 70(8)2021 Aug.
Article
in English
| MEDLINE | ID: covidwho-1376363
ABSTRACT
Following prolonged hospitalization that included broad-spectrum antibiotic exposure, a strain of Providencia rettgeri was cultured from the blood of a patient undergoing extracorporeal membrane oxygenation treatment for hypoxic respiratory failure due to COVID-19. The strain was resistant to all antimicrobials tested including the novel siderophore cephalosporin, cefiderocol. Whole genome sequencing detected ten antimicrobial resistance genes, including the metallo-ß-lactamase bla NDM-1, the extended-spectrum ß-lactamase bla PER-1, and the rare 16S methyltransferase rmtB2.
Subject(s)
Anti-Bacterial Agents/pharmacology , COVID-19/therapy , Drug Resistance, Bacterial , Enterobacteriaceae Infections/mortality , Pneumonia, Ventilator-Associated/mortality , Providencia/drug effects , Aged , COVID-19/complications , Enterobacteriaceae Infections/blood , Enterobacteriaceae Infections/etiology , Enterobacteriaceae Infections/microbiology , Extracorporeal Membrane Oxygenation , Fatal Outcome , Humans , Male , Microbial Sensitivity Tests , Pneumonia, Ventilator-Associated/etiology , Pneumonia, Ventilator-Associated/microbiology , Providencia/genetics , Providencia/isolation & purification
2.
Open Forum Infectious Diseases
; 7(Supplement_1):S303-S303, 2020.
Article
in English
| Oxford Academic | ID: covidwho-1010521